Prognostic Predictor for Colon Cancer

nloaded kground: The zinc finger transcription factor Krüppel-like factor 4 (KLF4) regulates numerous logic processes, including proliferation, differentiation, and development. Studies also showed that is involved in tumorigenesis and somatic cell reprogramming. Here, we aimed to assess whether is a prognostic indicator for colon cancer. thods: Levels of KLF4 were measured by immunohistochemical analysis of a tissue microarray contain7 independent colon cancer sections. Univariate data analysis was done in addition to construction of ariate models with several clinicopathologic factors to evaluate KLF4 as an independent predictor of al and cancer recurrence (disease-free survival). ults: Colon cancer tissues had significantly overall lower KLF4 levels compared with noncancer tissues .0001). Using logistic regression, a trend was noted for decreased odds of KLF4 expression in higher of tumors. In univariate and multivariate analyses, KLF4 was a significant predictor of survival and ence. clusions: KLF4 expression is significantly downregulated in colon cancer, and loss of KLF4 is an ndent predictor of survival and recurrence. indepe Impact: These findings suggest that KLF4 may serve as a prognostic biomarker for colon cancer. Cancer Epidemiol Biomarkers Prev; 19(10); 2631–8. ©2010 AACR.